UKB cares for around 500,000 patients per year, employs around 9,000 staff and has total assets of 1.6 billion euros. In addition to the more than 3,300 medical and dental students, a further 585 people are trained each year in numerous healthcare professions. The UKB is ranked first among university hospitals in NRW in the science ranking and in the Focus Clinic list and has the third-highest case mix index (case severity) in Germany.
Science and research
Full-time
PhD student (m/w/d) in T cell immunology/immune regulation in allogeneic stem cell transplantation and cellular immunotherapy
The Medical Clinic III at the University Hospital Bonn has the following full-time position (38,5 Std-/Woche) available as soon as possible:
PhD student (m/w/d) in T cell immunology/immune regulation in allogeneic stem cell transplantation and cellular immunotherapy
The position is initially project-related and limited for three years with the prospect of an extension of the employment.
Our “Laboratory for Experimental Stem Cell Transplantation and Cellular Therapy” focuses on basic and translational research assessing humoral and cellular immunoregulatory mechanisms during allogeneic stem cell transplantation and other cellular immunotherapies, mainly CAR T cells. Furthermore, we assess the impact of dietary habits on the immune function during those cell therapies. In addition, using nanobody technology we aim to identify new treatment options for malignant diseases.
Qa-1 restricted CD8+ regulatory T cells (Treg) are a newly identified T cell population in mice that play a major role in regulating immune responses in autoimmunity, infection and cancer. Recent analyses have defined thorough phenotypical and functional characteristics of this CD8+ T cell subset. However, the functional human homologue of Qa-1 restricted CD8+ Treg could not yet be established.
In this project, our laboratory seeks to further assess the role of murine CD8+ Treg in various disease models and additionally focuses on the identification of the human homologue of murine CD8+ Treg. We use the knowledge recently gained from murine experiments to define human HLA-E restricted CD8+ Treg and close collaborations with the Department of Hematology and Oncology of the University Hospital Bonn allow the assessment of this CD8+ T cell subset in human disease.
Your tasks
- Cell culture and extraction of primary immune cells
- Biobanking
- Molecular biology (PCR, gel electrophoresis, RNA and DNA extraction, qPCR)
- FACS analyses
- Immunohistochemistry
- Metabolic assays
- Work with mice (breeding, genotyping, nutritional studies, transfer experiments)
Your profile
We are looking for a highly motivated and talented PhD student with high interest in T cell immunology.
Your profile should include:
- Strong work commitment and discipline
- Diploma or master thesis in immunology, biology, biochemistry, biomedicine or similar
- Ability to work independently and as part of a team
- Good English communication skills
We offer:
- Dynamic, multidisciplinary and international environment with a strong focus on immunology.
- International Immunology Training Program, giving access to state-of-the-art training and workshops on different scientific aspects
- Weekly seminars on immunology and other biomedical topics by national and international speakers
- Possibility to present results at national and international conferences.
- Modern university sport facilities
- Salary according to the German scale TV-L 13 65% with additional benefits in the public sector such as pension plan and UKB corporate benefits
- Living in an active university city with access to internationally known museums, music and theatre venues and many other cultural possibilities in the Bonn-Cologne area
We offer
Future-proof employer
Future-proof employer
At UKB you are working on a hospital of the future. With an annual balance sheet of 1.6 billion in 2023, an annual surplus of over 21 million euros and the third-highest case mix index in Germany, UKB is excellently positioned for the future
Payment according to TV-L
Payment according to TV-L
Pay scale and performance-related remuneration according to TV-L / TV-Ä at university hospitals (incl. additional benefits such as annual bonuses)
Bonuses & special payments
Bonuses & special payments
In accordance with the TV-L, a special annual payment is made and there are other additional payments such as the bonus system for taking on additional tasks in the team, for selected additional qualifications, specialist further training and for permanent employment in the nursing pool. There is also a stand-in bonus for short-term assignments within < 96 hours from the duty-free allowance.
Advantages of the TV-E
Advantages of the TV-E
Additional benefit for relief in the areas entitled to TV-E (relief days)
Flexible working hours
Flexible working hours
Individual working time models, flexitime (for office jobs), home office
Start with a system
Start with a system
Structured onboarding, subject-specific and structured induction in an expert team, many practical instructors
Company pension scheme
Company pension scheme
Company pension scheme with the VBL and the option of deferred compensation for the clinic pension
Most attractive training center
Most attractive training center
Attractive training salary, predictable 38.5-hour week, 30 days of standard leave with 2 additional days of leave (TV-E), very good chances of being taken on after training, a training position in a collegial team with structured induction training
We are committed to diversity and equal opportunities.
Our aim is to increase the proportion of women in areas where women are underrepresented and to promote their careers.
to be particularly promoted. We therefore urge qualified women to apply. Applications will be handled in accordance with the state’s Equal Opportunities Act. Applications from suitable persons with a proven severe disability and persons with equivalent status are particularly welcome.
Applications (in German or English) are considered by email including a CV and the necessary certificates. Additionally, a brief statement of motivation should be attached until 18.06.2024.
Dr. med Tobias Holderried
Medizinische Klinik III
Labor für experimentelle Stammzelltransplantation und zelluläre Immuntherapie
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn
Tel.: +49 228 287 17233
E-Mail: tobias.holderried@ukbonn.de
