International Joint PhD position (m/f/d) Eye Clinic 03_2024

Universitätsklinikum Bonn

Das Universitätsklinikum Bonn
Wir vereinigen Exzellenz in Forschung, Lehre und Krankenversorgung sowie Wirtschaftlichkeit.

Im UKB werden pro Jahr etwa 500.000 Patient*innen betreut, es sind ca. 9.000 Mitarbeiter*innen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter den Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf.

  • Teilzeit
ab sofort

The following International Joint PhD position is to be filled as soon as possible in the Eye Clinic of the University Hospital Bonn as a part-time position (25,025 h/week):

International Joint PhD position (m/f/d)

Due to scholarship, the position is limited to 3 years, starting October 2024.

Project Summary: 

One fully funded project on cone photoreceptor in vitro differentiation for age-related macular degeneration modelling is available. This Joint PhD project will be primarily based at the University of Bonn with a minimum 12-month stay at the University of Melbourne.

https://findanexpert.unimelb.edu.au/opportunity/1202-aging-of-transdifferentiated-and-stem-cell-derived-human-photoreceptors

Project Details:

As rodent retinas lack a macula, age-related macular degeneration (AMD), which affects millions of patients worldwide, cannot be adequately replicated. However, human in vitro model systems, particularly cone photoreceptor cells, possess the potential to fill this void. The human macula is enriched with cone photoreceptors and facilitates high acuity, colour, and daytime vision. Transdifferentiation techniques exist to convert human fibroblasts to photoreceptors. Thereby, the cellular age is maintained, however the yield is very low. There are stem cell differentiation techniques available to generate photoreceptors in higher yields, but they remain immature, preventing AMD phenotypes from manifesting. This project will study transdifferentiation and stem cell differentiation in vitro to generate human cone photoreceptors in a comparative way. In-depth transcriptomic and epigenetic analyses with single-cell resolution will be performed to comprehend the molecular roadblocks, such as low yield or premature states. The molecular hurdles will then be adjusted to make transdifferentiation more efficient or to lead to mature and functional cone photoreceptors through stem cell differentiation. Ultimately, these cone photoreceptors will undergo AMD disease modelling to create new therapeutic interventions.

This project integrates cutting-edge cell and stem cell technologies, molecular biology, imaging, functional recordings, as well as epigenetic profiling and transcriptomic analysis at single-cell resolution. To comprehend severe human diseases like AMD, we require improved human model systems that can help develop effective therapies to prevent blindness.

We are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome.

The employment will only take place if the condition of the employment takes place in Melbourne.

This position is a scholarship.

https://www.uni-bonn.de/en/research-and-teaching/support-for-researchers-and-teachers/research-funding/university-grants/joint-doctoral-program-melbourne-bonn

How to apply:

Do you meet our requirements and are you looking for a varied and challenging job? Do not hesitate and send your detailed application (preferably by e-mail in one file up to 5 MB in size) until 27th of February 2024, stating the job advertisement number. 03_2024 to:

 

Dr. Sarah Kunze

Universitäts-Augenklinik Bonn

AG Busskamp

Ernst-Abbe-Str. 2

53127 Bonn

E-Mail: sarah.kunze@ukbonn.de

www.ukbonn.de

Wir setzen uns für Diversität und Chancengleichheit ein.

Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.

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