- Designing, performing experiments and analyzing results.
- Conceiving and developing new ideas, approaches or original technologies for studying gene regulation, fat metabolism and in general the lab’s research interests.
- Generating and recording data, protocols and/or code for publication.
- Drafting manuscripts and figures deriving from their own results.
- Interacting with and supporting other laboratory members.
- Sharing and discussing research results with key collaborators in the group, institute and among external collaborations.
- Presenting scientific results in relevant international meetings.
Postdoc (m/w/d) und PhD student (m/w/d) (Thermogenic fat biology) Institute of Pharmacology and Toxicology 753_2023
Universitätsklinikum Bonn
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Vollzeit
Das Universitätsklinikum Bonn
Wir vereinigen Exzellenz in Forschung, Lehre und Krankenversorgung sowie Wirtschaftlichkeit.
Im UKB werden pro Jahr etwa 500.000 Patient*innen betreut, es sind ca. 9.000 Mitarbeiter*innen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter den Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf.
ab sofort
The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.
At the Institute of Pharmacology and Toxicology of the University Hospital Bonn, University of Bonn, working group Prof. Dr. Yongguo Li, the following positions Postdoc (m/f/d) and PhD student (m/f/d) are available as soon as possible:
Postdoc (m/w/d) und PhD student (m/w/d)
(Thermogenic fat biology)
The research group of Prof. Dr. Yongguo is specialized in the role of adipose tissue in metabolism and energy balance. The overarching objective of the lab is, combining molecular and systems biology, leveraging the most cutting-edge technologies and multidisciplinary approaches, to decipher fundamental mechanisms that drive fat tissue remodeling, metabolic adaptation, and thermogenesis, which play central roles in the regulation of energy homeostasis. Ultimately, we seek to unravel potential therapeutically targetable mechanisms and promising drugs, which have fundamental implications for achieving metabolic health and combating metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Further information on our work: Bast-Habersbrunner EMBO Reports 2021, Li et al., Cell Reports 2019, Li et al., Cell 2018, Li et al., EMBO Reports 2014. For more info about the lab, please see: https://www.pharmakologie.uni-bonn.de/en/research/li-lab
The full-time positions are available immediately. The contracts run for 4 years due the project for PhD and minimal 2 years for Postdoc with the with the prospect of extension. The positions are funded by the Emmy Noether Program of the DFG (link) and ERC Starting Grant (link).
The successful candidates will employ various methods in molecular biology from basic cloning, analysis in cell culture, protein-biochemistry to Mass-Spec., RNA-Seq., ChIP-Seq, scRNA-Seq, high-resolution molecular imaging, genetic models as well as generation of further mouse mutant lines to devise a comprehensive molecular network that regulates white fat browning or a transformative molecular understanding of the cellular processes enabling physiological adaptation to thermogenic demand.
Ihre Aufgaben
Ihr Profil
- Applicants should have a Master of Science (M.Sc.) or equivalent academic degree in a field related to the research area. Experience in some of the mentioned techniques is also advantageous
- For the postdoc position, a PhD in either biology, biophysics, biochemistry or other relevant disciplines. PhD experience in the field of genetics and epigenetics is appreciated but not mandatory
- Profound knowledge and research experience in molecular biology, biochemistry, cell biology and advanced cell culture experience
- Knowledge/willingness of mouse experiment
- Knowledge and interest in fat biology
- Independence and flexibility in terms of managing projects and new ideas
- Fluency in English
Unser Angebot
- A thriving international and collaborative research environment, which is international, friendly, flexible, inclusive and scientifically excellent
- State-of-the-Art research platform
- Excellent supervision, mentorship and support by the PI and colleagues as well as regular group meetings and scientific events
- Attendance to national and international scientific meetings
- Benefits and salary according to the german payscale TV-L EG13
- Flexible working hours and work-life balance provisions
Kontakt
Applicants should send their application as a single pdf file (max. 10 MB), including motivation letter, CV, list of publications, academic degrees and name of two references. Please send your application by email under indication of the reference number 753_2023 until 10th October to:
Prof. Dr. Yongguo Li
Institut für Pharmakologie und Toxikologie
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn
E-Mail: ukb.ipt.li@gmail.com
www.ukbonn.de
Was wir Ihnen bieten:
Arbeitgeberleistungen
Vergünstigte Angebote für Mitarbeiter*innen
Attraktiver Standort
Eine abwechslungsreiche und anspruchsvolle Tätigkeit bei einem der größten Arbeitgeber im Raum Bonn
Bildung nach Maß
individuelle Entwicklungschancen durch zahlreiche geförderte Fort- und Weiterbildungsmöglichkeiten (Kurse, E-learning, Coaching etc.)
Clever zur Arbeit
Zinsloses Darlehen für ein E-Bike
Flexibel für Familien
individuelle Arbeitszeitmodelle, Betriebskita
Gesund am Arbeitsplatz
Zahlreiche Angebote der Gesundheitsförderung (BGM, Fitnessstudio, Hochschulsport)
Sicherer Arbeitgeber
Tarifliche und leistungsgerechte Vergütung nach TV-L / TV-Ä an Universitätskliniken (inkl. Zusatzleistungen)
Start mit System
Fachspezifische und strukturierte Einarbeitung in einem fachkundigen Team
Vorsorgen für später
Betriebliche Altersvorsorge bei der VBL sowie die Möglichkeit der Entgeltumwandlung bei der Klinikrente
Wir setzen uns für Diversität und Chancengleichheit ein.
Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.
